Humatrope by Eli Lilly has been used since 1987 as a treatment for growth deficiency in children but is now used for adult patients who wish to restore levels to normal. It comes in two delivery systems: pens and vials.



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Humatrope is a synthetic human growth hormone (HGH) that treats growth hormone deficiency (GHD) in children and adults. Growth hormone is crucial in various physiological processes, including growth, metabolism, and cellular repair. The development of Humatrope has been a groundbreaking advancement in medical science, providing numerous benefits for patients with growth hormone deficiencies. 

Definition of Humatrope

Humatrope is a brand name for the synthetic human growth hormone Eli Lilly, and Company produced. It is a sterile, lyophilized powder that contains recombinant somatropin, a bioengineered form of the natural growth hormone produced by the pituitary gland. Humatrope is administered through subcutaneous injections and is available in various vial sizes and strengths, depending on the patient’s needs.

Mechanism of Action

The human growth hormone somatropin acts on various tissues throughout the body by binding to specific receptors. This binding triggers a signaling cascade that stimulates the production of insulin-like growth factor 1 (IGF-1) in the liver and other tissues. IGF-1 plays a pivotal role in promoting growth and cellular replication. In children, Humatrope stimulates skeletal growth and increases the number and size of muscle cells. In adults, it helps maintain proper metabolism and body composition.

Benefits of Humatrope

Stimulates Growth in Children

One of the primary indications for Humatrope is treating children with growth hormone deficiency. By supplementing the deficient growth hormone, Humatrope stimulates skeletal growth, improving height and overall development in these children.

Improves Body Composition

In both children and adults, Humatrope can help increase lean body mass while reducing body fat. This is particularly beneficial for adults with growth hormone deficiency, who may experience muscle wasting and increased adipose tissue.

Enhances Bone Density

Humatrope has been shown to increase bone mineral density, making it beneficial for children with growth hormone deficiency as it aids in skeletal development and adults with low bone density or osteoporosis.

Boosts Exercise Performance

Athletes have occasionally misused HGH for its potential to enhance exercise performance. However, it’s important to note that such use is illegal and banned in sports due to potential health risks and ethical concerns.

Anti-Aging Effects

There is ongoing research on the potential anti-aging effects of HGH, but the evidence is still inconclusive. Some studies suggest that HGH might improve skin elasticity and reduce the appearance of wrinkles, but further research is needed to confirm these effects.

Supports Muscle Repair and Recovery

Humatrope may support muscle recovery and repair after exercise, improving athletic performance for athletes and individuals engaged in intense physical activities.

Side Effects of Humatrope

Although Humatrope is generally well-tolerated, it can cause some side effects, significantly when misused or inappropriately dosed. Common side effects include:

Injection Site Reactions

Some individuals may experience redness, pain, or swelling at the injection site. Rotating injection sites can help minimize this issue.

Joint and Muscle Pain

Some patients may experience joint and muscle pain as a side effect of Humatrope therapy, which usually resolves with time.

Fluid Retention

In rare cases, Humatrope may cause fluid retention, leading to swelling in the extremities.

Carpal Tunnel Syndrome

Some individuals may experience symptoms of carpal tunnel syndrome, such as hand tingling or numbness.


Humatrope can affect blood sugar levels, leading to hyperglycemia in some patients. Regular monitoring of blood glucose levels is essential for those with diabetes or prediabetes.


Humatrope may affect thyroid function, leading to hypothyroidism in some individuals. Regular thyroid function tests are recommended during treatment.

Dosage Guidelines for Humatrope

The appropriate dosage of Humatrope varies depending on the patient’s age, weight, medical condition, and the severity of growth hormone deficiency. The dosage is typically expressed in international units (IU) and administered via subcutaneous injections. Only a qualified healthcare professional should determine the dosage and administration schedule.

The usual starting dose for children with growth hormone deficiency is 0.1 to 0.3 mg per kg of body weight per week, divided into daily injections. The amount may be adjusted over time to achieve optimal growth.

The typical starting dose for adults with growth hormone deficiency is 0.1 to 0.2 mg daily, gradually increasing based on individual response and IGF-1 levels.

Following the prescribed dosage and not exceeding the recommended amount is crucial, as excessive HGH can lead to adverse effects. Regular monitoring by a healthcare provider is essential to ensure the therapy’s effectiveness and safety.


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